SYLLABUS
OSAKA UNIVERSITY SHORT-TERM STUDENT EXCHANGE PROGRAM _
99f-10 INTRODUCTION TO PHARMACEUTICAL SCIENCES
Keiichi TANAKA, Masayoshi IMAGAWA, Takefumi DOI, Yuji KOBAYASHI, Naoyoshi MAEZAKI, Hatsuo MAEDA, Hiroshi YAMAMOTO, Shinsaku NAKAGAWA and Kiyohito YAGI (Graduate School of Pharmaceutical Sciences)

Objective
This course gives foreign students an introduction to chemical, biological, and environmental pharmaceutical sciences and their recent progress in Japan. This course is primarily intended for international graduate students from other disciplines in the Faculty of Pharmaceutical Sciences, but we reform it suitable to undergraduate students in the short-term student exchange program.

Textbook
No particular text book is used. Some materials will be distributed in the class.

Lecture Outline
Week 1.An introduction to pharmaceutical sciences in the Faculty (Guidance)
Week 2.Environmental toxicology
Diseases produced by environmental pollutants in Japan
Week 3.Molecular toxicology
Molecular mechanisms of biological responses to environmental pollutants
Week 4.Molecular medicine
Molecular biology of atherosclerosis
Week 5.Technical tour and discussion
Facilities concerning environmental systems
Week 6.Biophysical Chemistry
Structure of bioactive macromolecule
Week 7.Synthetic organic chemistry
Strategies for synthesis of biologically active natural products
Week 8.Analytical chemistry
Importance of analytical chemistry in development of new medicines
Week 9.Modern instrumentation (Laboratory demonstration)
Theory and practice of modern instrumental techniques in chemical analysis
Week 10.Neuroimmunology
Environmental or emotional stress alters immune responses
Week 11.Gene therapy
Development of fusogenic liposome and application for genetherapy
Week 12.Production of medicine by cell culture
Microbial production of antibiotics; large-scale cultivation of animal cells; use of recombinant DNA technology
Week 13.Laboratory demonstration and discussion
Cultivation of microorganisms; demonstration of antibiotic titer
Week 14-15.Final examination (Term paper preparation)

Grading
The course grade will be based upon a term paper to be submitted at the end of the course (60%) and class participation and discussion (40%).

OUSSEP _
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